What Is Creatine? Creatine is a naturally occurring compound made from amino acids that is stored primarily in muscles and the brain. It helps produce quick energy for high-intensity movement, strength, and cellular function. Although the body naturally produces creatine and it’s found in foods like red meat and fish, supplementation can help increase the body’s creatine stores beyond what diet alone typically provides. Creatine is one of the most extensively studied suppleme